Mono-POC Isopropyl Tenofovir
| Product Name | Mono-POC Isopropyl Tenofovir |
|---|---|
| Alternate Names | Tenofovir Impurities, Impurities of Tenofovir |
| CAT No. | CS-O-10863 |
| CAS No. | 1246812-40-7 |
| Category | Impurities |
| Stock | IN-Stock |
| Mol. Wt. | 445.41 g/mol |
| Mol. For. | C₁₇H₂₈N₅O₇P |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Tenofovir |
| Purity | For long term usage store at -20?C |
| Therapeutic | Antiretroviral / Anti-HIV |
| Smileys | C[C@@H](OC[P](OCOC(OC(C)C)=O)(OC(C)C)=O)CN1C2=NC=NC(N)=C2N=C1 |
| Canonical Smiles | CC(C)OC(=O)OCOP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OC(C)C |
| InchIKey | IHJDJJPKNNEZLC-SGSXECEGSA-N |
| Inchl | InChI=1S/C17H28N5O7P/c1-11(2)28-17(23)25-9-27-30(24,29-12(3)4)10-26-13(5)6-22-8-21-14-15(18)19-7-20-16(14)22/h7-8,11-13H,6,9-10H2,1-5H3,(H2,18,19,20)/t13-,30?/m1/s1 |
| IUPAC | [[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-propan-2-yloxyphosphoryl]oxymethyl propan-2-yl carbonate |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Mono-POC Isopropyl Tenofovir is a potent nucleotide reverse transcriptase inhibitor that is used for the treatment of HIV-1 infection. It is a prodrug of tenofovir, which is converted into its active form, tenofovir diphosphate, in vivo. Mono-POC Isopropyl Tenofovir is designed to have improved pharmacokinetic properties, which allows for once-daily dosing and better patient compliance.
Chemically, Mono-POC Isopropyl Tenofovir is an ester of isopropyl alcohol and tenofovir. The isopropyl group in the molecule enhances its lipophilicity, which allows for better absorption and distribution in the body. The prodrug is rapidly hydrolyzed by esterases in the blood, releasing tenofovir.
Tenofovir diphosphate inhibits the activity of reverse transcriptase, which is essential for the replication of HIV-1. It competes with the natural substrate, deoxyadenosine triphosphate, and incorporates itself into the growing DNA chain, leading to chain termination. Tenofovir diphosphate also inhibits the activity of viral DNA polymerase, which further reduces viral replication.
Mono-POC Isopropyl Tenofovir is administered orally and is rapidly absorbed from the gastrointestinal tract. It has a long half-life of approximately 17 hours, which allows for once-daily dosing. The drug is primarily eliminated via the kidneys, and dosage adjustments are necessary in patients with renal impairment. Overall, Mono-POC Isopropyl Tenofovir is an effective and well-tolerated treatment for HIV-1 infection.
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Related Compounds
Tenofovir Alafenamide Dimer impurity | Tenofovir alafenamide (RRS) diasteroisomer | Desmethyl Tenofovir Disoproxil Fumarate | Tenofovir diphosphate | Tenofovir alafenamide Methyl ester impurity | Mono-POC Ethyl Tenofovir | Tenofovir EP Impurity C Succinate | Tenofovir isomer 6&1 | Tenofovir Related Compound 5 | Tenofovir Bis ((R)-9-(2-Hydroxypropyl)adenine) dimer Acetate salt | Mono-POC Methyl Tenofovir Fumarate (Mixture of Diastereomers) | Tenofovir Alafenamide (RSR) Diasteroisomer | Tenofovir alafenamide Impurity 1 | Tenofovir Alanine ester impurity | Tenofovir Disoproxil (S)-Isomer fumarate salt | Tenofovir Disoproxil T11 Impurity | Tenofovir Impurity 98 | TAF SRS diastereomer | Tenofovir Impurity 36 (RSR) 2,3-dihydroxysuccinate salt | Tenofovir Disoproxil T8 Impurity | Tenofovir Impurity 89 | Tenofovir alafenamide Impurity 2 | Ethyl Tenofovir Impurity | Tenofovir Diphenyl HemiFumarate salt | Diethylaminocarboxymethyl POC Tenofovir (Mixture of Diastereomers) | Tenofovir Disoproxil Isopropoxycarbonyl | Tenofovir DP-V | Tenofovir Alafenamide N-hydroxy methyl impurity | Tenofovir alafenamide Impurity 5 | Tenofovir Impurity 59-D6 | Tenofovir Mono POC Dimer Diethyl amine salt | Tenofovir alafenamide impurity | Tenofovir Impurity 62 | Tenofovir disoproxil impurity L fumarate | Mono poc-isopropyl-Tenofovir fumarate salt | Tenofovir Impurity 35 | Tenofovir Isopropyl Carbamate | Tenofovir alafenamide lactose Millard Reaction product-3 | tenofovir related impurity | Tenofovir Monomethyl Ester | Tenofovir Impurity 59 | Tenofovir Impurity 65 | Tenofovir disoproxil phosphate | Tenofovir alafenamide lactose Millard Reaction product-2 | Tenofovir Alfenamide Amadori Rearrangement product | Tri-POC Tenofovir Dimer | Tenofovir alafenamide Impurity 3 | Mono ester impurity (Tenofovir) | Tenofovir Related Compound 14 | Mono-POC Tenofovir 6-Isopropyl Carbamate | TAF Propyl ester Impurity | Tenofovir Disoproxil T7 Impurity | TAF methyl ester | Diisopropyl Tenofovir Fumarate | Isopropyl Tenofovir | Tenofovir Alafenamide Enantiomer | Tenofovir Disoproxil T5 Impurity | MOC-POC Tenofovir Fumarate | Tenofovir impurity C fumarate salt | Tenofovir Alafenamide Glycosamine product | Tenofovir Mixed dimer | Tenofovir Alafenamide Dimer Impurity II | nPOC-POC Tenofovir Fumarate | nPOC-POC Tenofovir | Tenofovir disoproxil impurity L | Tenofovir Impurity 39 (RRR) 2,3-dihydroxysuccinate salt | TenofovirDisoproxil Ethyl fumarate Impurity | Tenofovir DP-IV | MOC-POC Tenofovir | Tenofovir alafenamide monofumarate |