Alogliptin D3
| Product Name | Alogliptin D3 |
|---|---|
| Alternate Names | Alogliptin Stable Isotopes, Stable Isotopes of Alogliptin |
| CAT No. | CS-T-47577 |
| CAS No. | 1133421-35-8 |
| Category | Stable Isotopes |
| Stock | Enquire |
| Mol. Wt. | 342.4 g/mol |
| Mol. For. | C18H18D3N5O2 |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Alogliptin |
| Purity | 95% |
| Therapeutic | Anti-Diabetic |
| Canonical Smiles | CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCCC(C3)N |
| InchIKey | ZSBOMTDTBDDKMP-DDOHFVCQSA-N |
| Inchl | InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1/i1D3 |
| IUPAC | 2-[[6-[(3R)-3-aminopiperidin-1-yl]-2,4-dioxo-3-(trideuteriomethyl)pyrimidin-1-yl]methyl]benzonitrile |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Alogliptin D3 is a deuterated form of the antidiabetic drug Alogliptin. It is a potent and selective inhibitor of dipeptidyl peptidase-4 (DPP-4), an enzyme responsible for the degradation of incretin hormones such as glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP). By inhibiting DPP-4, Alogliptin D3 increases the levels of GLP-1 and GIP in the bloodstream, which in turn stimulates insulin secretion from pancreatic beta-cells and suppresses glucagon secretion from alpha-cells. This results in improved glycemic control in patients with type 2 diabetes mellitus.
Alogliptin D3 is available in tablet form for oral administration. The recommended dose is 25 mg once daily, with or without food. It has a half-life of approximately 21 hours and is primarily eliminated through renal excretion.
Chemically, Alogliptin D3 is a white to off-white crystalline powder with a molecular formula of C18H12D3F2N5O2 and a molecular weight of 339.38 g/mol. It is soluble in dimethyl sulfoxide and slightly soluble in water and methanol. The deuterium substitution in Alogliptin D3 enhances its pharmacokinetic properties, such as increased metabolic stability and reduced clearance, compared to the non-deuterated Alogliptin. Alogliptin D3 is also less prone to drug-drug interactions and less affected by genetic polymorphisms that may affect the metabolism of the non-deuterated drug.
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Related Compounds
Alogliptin 13C6 | Alogliptin D9 | Alogliptin 13C D3 |