5-Dehydroxy (3S)-Atorvastatin

5-Dehydroxy (3S)-Atorvastatin is a chemical compound used for the treatment of high cholesterol and the prevention of cardiovascular diseases. It is a derivative of Atorvastatin which is a well-known cholesterol-lowering drug. The compound works by inhibiting the enzyme HMG-CoA reductase, which is responsible for the production of cholesterol in the liver. This leads to a reduction in the amount of LDL (low-density lipoprotein) cholesterol in the blood, which is responsible for the formation of plaques in the arteries. The chemical structure of 5-Dehydroxy (3S)-Atorvastatin contains a lactone ring, a dihydroxyheptenoic acid side chain, and a tetrahydrofuran ring. The compound is a white crystalline powder with a molecular weight of 558.67 g/mol. It is sparingly soluble in water but soluble in organic solvents like ethanol and methanol. The recommended dosage of 5-Dehydroxy (3S)-Atorvastatin is usually 10-80 mg per day, depending on the severity of the patient's condition. The compound is metabolized in the liver and eliminated through feces and urine. It should not be used by pregnant women or individuals with liver disease. In conclusion, 5-Dehydroxy (3S)-Atorvastatin is an effective medication for the treatment of high cholesterol and the prevention of cardiovascular diseases. Its chemical structure and mechanism of action make it a valuable tool in the fight against these conditions.