Diltiazem N-Oxide
| Product Name | Diltiazem N-Oxide |
|---|---|
| Alternate Names | Diltiazem Impurities, Impurities of Diltiazem |
| CAT No. | CS-T-90720 |
| CAS No. | 142843-04-7 |
| Category | Impurities |
| Stock | IN-Stock |
| Mol. Wt. | 430.52 g/mol |
| Mol. For. | C22H26N2O5S |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Diltiazem |
| Smileys | O=C1[C@H](OC(C)=O)[C@H](C2=CC=C(OC)C=C2)SC3=CC=CC=C3N1CC[N+](C)(C)[O-] |
| Canonical Smiles | CC(=O)OC1C(SC2=CC=CC=C2[N+](C1=O)(CCN(C)C)[O-])C3=CC=C(C=C3)OC |
| InchIKey | VMYITXJQDGPHNJ-JBAPTLGWSA-N |
| Inchl | InChI=1S/C22H26N2O5S/c1-15(25)29-20-21(16-9-11-17(28-4)12-10-16)30-19-8-6-5-7-18(19)24(27,22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+,24?/m1/s1 |
| IUPAC | [(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-5-oxido-4-oxo-2,3-dihydro-1,5-benzothiazepin-5-ium-3-yl] acetate |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Diltiazem N-Oxide is a potent and selective inhibitor of L-type calcium channels. It is a derivative of diltiazem, which is commonly used to treat hypertension and angina. Diltiazem N-Oxide is used primarily as a research tool to study the role of L-type calcium channels in various physiological and pathological conditions.
The chemical structure of Diltiazem N-Oxide includes an N-oxide group, which is responsible for its unique pharmacological properties. This group is known to undergo rapid reduction in vivo, leading to the formation of the parent compound diltiazem. This process is thought to contribute to the pharmacokinetics and pharmacodynamics of Diltiazem N-Oxide.
In vitro studies have shown that Diltiazem N-Oxide is a potent inhibitor of L-type calcium channels, with an IC50 value in the low micromolar range. It has also been shown to have selectivity for this channel subtype over other calcium channels. This selectivity makes Diltiazem N-Oxide a valuable tool for investigating the specific roles of L-type calcium channels in various cellular processes.
Overall, Diltiazem N-Oxide is a useful research tool for investigating the physiology and pharmacology of L-type calcium channels. Its unique chemical structure and pharmacological properties make it a valuable addition to the research arsenal of scientists studying cardiovascular and neurological diseases.
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Related Compounds
Diltiazem dihydrolysed impurity | Not in use Diltiazem related compound G | N,N-Didesmethyl N-tert-Butoxycarbonyl Diltiazem | Diltiazem EP Impurity C Hydrochloride (O-Desmethyl Diltiazem Hydrochloride) | DTZ-II Diltiazem impurity | Diltiazem DTZ-I Impurity | Diltiazem monohydrolysed impurity | Deacetyl o-demethyl diltiazem | N,N-didesmethyl diltiazem | N-Acetyl Diltiazem | Diltiazem Impurity 1 | rel-N-Desmethyl Desacetyl Diltiazem | Diltiazem related compound H | Deacetyl Diltiazem N-Oxide | dl-cis-Diltiazem | Diltiazem formamide impurity | Acetoxy Lactam Diltiazem | Diltiazem Impurity 2 | Diltiazem Impurity G (N-Desmethyl Desacetyl Diltiazem Hydrochloride) | N,N-Didesmethyl Diltiazem Hydrochloride | Diltiazem Epoxide (2R,3S) Isomers | Diltiazem-d3 Hydrochloride | Diltiazem EP Impurity A | N-desmethyl N-nitroso Diltiazem | Diltiazem Sulphone | N-nitroso intermediate Stage-1A (Diltiazem) | Diltiazem EP Impurity C | O-Desmethyldiltiazem |