(±)-Norgestrel D6

Norgestrel D6 is a synthetic progestin and one of the most commonly used oral contraceptives in the world. It is a derivative of norethisterone and is used alone or in combination with other hormones to prevent pregnancy. Norgestrel D6 works by thickening the cervical mucus, which prevents sperm from reaching the egg, and by changing the lining of the uterus, which makes it difficult for a fertilized egg to attach and grow. Norgestrel D6 is a white to off-white crystalline powder that is practically insoluble in water and sparingly soluble in ethanol. Its molecular formula is C21H26O2 and its molecular weight is 310.44 g/mol. The "D6" designation indicates that six of the hydrogen atoms in the molecule have been replaced with deuterium, a stable isotope of hydrogen. This labeling is often used in pharmacokinetic studies to track the fate of the drug in the body. Norgestrel D6 is typically taken orally once a day for 21 days, followed by a 7-day break to allow for menstruation. It is important to take the medication at the same time every day to maintain its effectiveness. Common side effects of Norgestrel D6 include nausea, headache, breast tenderness, and changes in menstrual bleeding. Serious side effects such as blood clots, stroke, and liver damage are rare but can occur, particularly in women who smoke or have other risk factors. Overall, Norgestrel D6 is a safe and effective form of contraception when used properly and under the guidance of a healthcare provider.