[13C5]-Guanosine monohydrate

[13C5]-Guanosine monohydrate is a labeled version of guanosine, a nucleoside that is composed of a purine base (guanine) and a ribose sugar. The label indicates that five of the carbon atoms in the guanine base have been replaced with carbon-13, a stable, non-radioactive isotope of carbon. This labeling can be useful in a variety of applications, including metabolic studies and drug development. One common use of [13C5]-Guanosine monohydrate is in the study of nucleic acid metabolism. Specifically, researchers can track the fate of the labeled guanosine in cells or tissues to gain insight into how nucleotides are synthesized, degraded, and recycled. This information can be important for understanding diseases such as cancer, which often involve alterations in nucleotide metabolism. In drug development, [13C5]-Guanosine monohydrate can be used to screen potential drug candidates that target nucleotide metabolism. By measuring the uptake and incorporation of the labeled guanosine into nucleic acids, researchers can determine whether a drug is affecting nucleotide synthesis or turnover. From a chemical standpoint, [13C5]-Guanosine monohydrate is a white crystalline powder that is soluble in water. Its chemical formula is C10H12N5O5P•H2O, indicating that it contains one molecule of water per molecule of guanosine monophosphate. The labeled carbon atoms are located at positions 2, 4, 5, 8, and 9 in the guanine base.