[13C5]-Pemetrexed

[13C5]-Pemetrexed is a labeled derivative of the chemotherapy drug Pemetrexed. It contains five carbon-13 isotopes which can be used for further research and analysis of drug metabolism and pharmacokinetics. Pemetrexed is used in the treatment of various cancers such as lung cancer, mesothelioma, and non-small cell lung cancer. This medication works by inhibiting the enzymes involved in the synthesis of purines and pyrimidines, which are essential building blocks of DNA and RNA. By inhibiting these enzymes, Pemetrexed can effectively prevent the growth and proliferation of cancer cells. [13C5]-Pemetrexed can be used in pharmacokinetic studies to determine the absorption, distribution, metabolism, and excretion of Pemetrexed. Researchers can use this labeled derivative to track the drug's movement throughout the body and identify any potential sites of metabolism. It can also be used to monitor the effectiveness of the drug in patients and determine appropriate dosages for treatment. In terms of chemical information, [13C5]-Pemetrexed has a molecular weight of 454.54 g/mol and a molecular formula of C20H19N5O6. It is a white to off-white powder that is soluble in water and methanol. The labeled derivative has a purity of at least 98% and is stable under recommended storage conditions. Overall, [13C5]-Pemetrexed is a valuable tool for researchers studying the pharmacokinetics and metabolism of Pemetrexed for the treatment of cancer.