[13C6]-Ebastine

[13C6]-Ebastine is a stable isotope-labeled form of Ebastine, a second-generation antihistamine drug used for the treatment of allergies and hay fever. The stable isotopes in [13C6]-Ebastine are six carbon-13 atoms, which do not affect the pharmacological properties of the drug but allow for its detection and quantification in biological samples using mass spectrometry techniques. The usage of [13C6]-Ebastine is mainly in pharmacokinetic and pharmacodynamic studies to investigate the drug's metabolism, bioavailability, and elimination pathways in humans and animals. The labeled compound is administered orally or intravenously to the subjects, and the labeled carbon atoms are traced in the drug or its metabolites through urine, blood, or tissue samples. Chemically, [13C6]-Ebastine is a selective histamine H1 receptor antagonist that blocks the action of histamine, a chemical released by the immune system that causes allergic symptoms such as itching, sneezing, and runny nose. The drug has a long duration of action, up to 48 hours, and is metabolized in the liver by cytochrome P450 enzymes to its active metabolite, carebastine. The stable isotope labeling of [13C6]-Ebastine provides a valuable tool for drug development and clinical research, allowing for accurate and sensitive quantification of the drug and its metabolites in biological matrices and improving the understanding of its pharmacokinetics and pharmacodynamics.