[13C6]-Fosaprepitant

[13C6]-Fosaprepitant is a stable isotope-labeled form of the antiemetic drug fosaprepitant. Fosaprepitant is a prodrug of aprepitant, which is a selective neurokinin-1 receptor antagonist. It is used to prevent nausea and vomiting caused by chemotherapy and surgery. [13C6]-Fosaprepitant is used in clinical research studies to investigate the pharmacokinetics and metabolism of fosaprepitant in humans. The stable isotopes in [13C6]-Fosaprepitant enable researchers to track the drug's metabolic pathways in the body. This information is important for determining the drug's efficacy, safety, and dosing requirements. Specifically, [13C6]-Fosaprepitant is used in studies that involve isotope dilution mass spectrometry (IDMS) analysis. IDMS is a highly precise analytical method that is used to measure drug concentrations in biological samples. [13C6]-Fosaprepitant is synthesized using stable carbon isotopes, which are non-radioactive and have a longer half-life than radioactive isotopes. The labeling of the drug with six carbon-13 atoms does not alter its pharmacological activity or side effect profile. Thus, it is a safe and effective tool for clinical research. In summary, [13C6]-Fosaprepitant is a stable isotope-labeled form of fosaprepitant that is used in clinical research to investigate the pharmacokinetics and metabolism of the drug. Its usage enables researchers to better understand the drug's mechanisms of action and optimize its therapeutic benefits.