[13C6]-Retigabine

[13C6]-Retigabine is a stable isotope labeled form of Retigabine, a drug used for the treatment of epilepsy. Retigabine, also known as Ezogabine, is a potassium channel opener that works by stabilizing the neuronal membrane potential and reducing the excitability of neurons. This drug is specifically used for the treatment of partial-onset seizures in patients with epilepsy who have not responded to other treatments. The stable isotope labeled form of Retigabine, [13C6]-Retigabine, is used in pharmacokinetic studies to determine the drug's metabolism, absorption, and excretion in the body. It is also used in the development of new analytical methods for the detection and quantification of Retigabine in biological samples. Chemically, [13C6]-Retigabine has the same molecular formula as Retigabine, C16H18ClN3O, but six of its carbon atoms are replaced with the stable carbon isotope, ^13C. This labeling allows for the accurate detection and measurement of the drug in biological samples using mass spectrometry. Overall, [13C6]-Retigabine plays an important role in the development and understanding of the pharmacokinetics and pharmacodynamics of Retigabine, as well as in the development of new analytical methods for the detection and quantification of the drug in biological samples.