[15N4]-Azacitidine

[15N4]-Azacitidine is a modified version of the chemotherapy drug Azacitidine, which is used to treat certain types of blood cancers such as myelodysplastic syndrome. [15N4]-Azacitidine is labeled with four nitrogen-15 isotopes, which allows for easy tracking and analysis of the drug in biological systems. The chemical structure of [15N4]-Azacitidine is similar to that of Azacitidine, with the addition of the nitrogen-15 isotopes. It works by inhibiting the activity of DNA methyltransferase enzymes, which are involved in the regulation of gene expression. By inhibiting these enzymes, [15N4]-Azacitidine can help to re-activate genes that have been silenced in cancer cells, leading to their destruction. [15N4]-Azacitidine is typically administered by injection into the bloodstream, and the dosage and frequency of treatment will depend on the individual patient's condition and response to the drug. It may also be used in combination with other chemotherapy drugs or treatments. As with any medication, [15N4]-Azacitidine may cause side effects such as nausea, vomiting, fatigue, and low blood cell counts. Patients should be closely monitored by their healthcare team during treatment with this drug. Overall, [15N4]-Azacitidine is an important tool in the fight against certain types of blood cancers, and its isotopic labeling provides valuable insights into its pharmacokinetics and mechanism of action.