[2'-13C]2'-deoxyadenosine monohydrate

[2'-13C]2'-deoxyadenosine monohydrate is a stable, isotopically-labeled nucleoside that is widely used in research related to nucleoside metabolism, nucleic acid synthesis, and drug discovery. This compound is a derivative of 2'-deoxyadenosine, an essential building block of DNA that plays a critical role in the replication and repair of genetic material. The isotopic labeling of [2'-13C]2'-deoxyadenosine monohydrate is achieved by replacing the carbon atom at position 2' of the ribose sugar with a stable, non-radioactive isotope of carbon (carbon-13). The usage of [2'-13C]2'-deoxyadenosine monohydrate is primarily focused on the study of nucleoside metabolism and the biosynthesis of DNA. Researchers can use this compound as a tracer to investigate the fate of nucleosides in biological systems, monitoring the incorporation of labeled nucleosides into DNA and other cellular components. Additionally, [2'-13C]2'-deoxyadenosine monohydrate can be used to study the mechanisms of action of drugs that target nucleoside metabolism, providing insight into potential new treatments for diseases such as cancer and viral infections. From a chemical standpoint, [2'-13C]2'-deoxyadenosine monohydrate is a white to off-white crystalline powder that is stable under normal storage conditions. It has a molecular formula of C10H12N5O3 and a molecular weight of 256.24 g/mol. The isotopic labeling of the compound is confirmed by nuclear magnetic resonance (NMR) spectroscopy, which is used to analyze the carbon-13 signal in the molecule. Overall, [2'-13C]2'-deoxyadenosine monohydrate is a valuable tool for researchers studying nucleoside metabolism and DNA synthesis, providing a precise and reliable means of tracking nucleoside uptake and incorporation into cellular components.