[2',2''-D2]2'-deoxyguanosine monohydrate

[2',2''-D2]2'-deoxyguanosine monohydrate is a deuterated form of the nucleoside 2'-deoxyguanosine. It is commonly used as a stable isotope labeled internal standard in various analytical techniques such as mass spectrometry and nuclear magnetic resonance spectroscopy. The deuterium atoms replace the hydrogen atoms in the molecule, which enhances the sensitivity and accuracy of the analytical method. Chemically, [2',2''-D2]2'-deoxyguanosine monohydrate is a purine nucleoside composed of a deoxyribose sugar and a guanine base. The deuterium atoms are located at the 2' and 2'' positions of the sugar moiety. Its molecular formula is C10H13D2N5O4H2O, with a molecular weight of 307.3 g/mol. In addition to its use as an internal standard, [2',2''-D2]2'-deoxyguanosine monohydrate also has potential applications in studying DNA replication and repair mechanisms. Its deuterated form can be incorporated into DNA molecules, enabling researchers to track the fate of deoxyguanosine in DNA synthesis and repair processes. Overall, [2',2''-D2]2'-deoxyguanosine monohydrate is a valuable tool in both analytical chemistry and biological research, with potential applications in various fields including pharmacology, toxicology, and cancer research.