(R)-Cinacalcet-D3 Hydrochloride

Product Name (R)-Cinacalcet-D3 Hydrochloride
Alternate Names Cinacalcet Stable Isotopes, Stable Isotopes of Cinacalcet
CAT No. CS-F-00068
CAS No. 364782-34-3 (unlabelled)
Category Stable Isotopes
Stock Enquire
Mol. Wt. 396.89 g/mol
Mol. For. C22H20D3ClF3N
Hazardous This is not a Hazardous Compound
COA View Sample COA
MSDS View Sample MSDS
Parent API Cinacalcet
Controlled No
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(R)-Cinacalcet-D3 Hydrochloride is a chemical compound that is used as a medication for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease. It is a synthetic analog of calcimimetic cinacalcet that has been deuterated to enhance its stability and efficacy. The compound works by binding to the calcium-sensing receptor on the parathyroid gland, which regulates the secretion of parathyroid hormone (PTH). This results in a decrease in the secretion of PTH, which in turn reduces the levels of calcium and phosphorus in the blood. The chemical formula of (R)-Cinacalcet-D3 Hydrochloride is C22H19D3ClF2N, and its molecular weight is 370.90 g/mol. It is an off-white to pale yellow crystalline powder that is sparingly soluble in water and soluble in methanol and ethanol. The compound is typically administered as an oral tablet, with a recommended starting dose of 30 mg once daily. The dose may be adjusted based on the patient's response and serum calcium levels. (R)-Cinacalcet-D3 Hydrochloride is metabolized in the liver and excreted in the feces and urine. It is primarily metabolized by cytochrome P450 enzymes, particularly CYP3A4 and CYP2D6. The half-life of the compound is approximately 30-40 hours, and it takes about 5-7 days to reach steady-state concentrations in the blood. Overall, (R)-Cinacalcet-D3 Hydrochloride is an effective medication for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease. Its deuterated analog enhances its stability and efficacy, making it a valuable addition to the armamentarium of treatments for this condition.

Related Compounds

Rac-Cinacalcet D3 Hydrochloride | Cinacalcet D3 Hydrochloride | Cinacalcet D3 | Cinacalcet-d4 Hydrochloride | Cinacalcet D4 |

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