(R)-Hydroxy Des(boric Acid) Bortezomib

Product Name (R)-Hydroxy Des(boric Acid) Bortezomib
CAT No. CS-T-27111
CAS No. 289472-78-2
Category Impurities
Stock IN-Stock
Mol. Wt. 356.42 g/mol
Mol. For. C₁₉H₂₄N₄O₃
Hazardous This is a Hazardous Compound
COA View Sample COA
MSDS View Sample MSDS
Therapeutic Synthetic Peptides
Canonical Smiles CC(C)CC(NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)O
InchIKey NEIDLJIPMZVISC-DOTOQJQBSA-N
Inchl InChI=1S/C19H24N4O3/c1-13(2)10-17(24)23-18(25)15(11-14-6-4-3-5-7-14)22-19(26)16-12-20-8-9-21-16/h3-9,12-13,15,17,24H,10-11H2,1-2H3,(H,22,26)(H,23,25)/t15-,17+/m0/s1
IUPAC N-[(2S)-1-[[(1R)-1-hydroxy-3-methylbutyl]amino]-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide
Controlled No
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Size Price Quantity
2.5 MG $  152.00
$ 160.00
25 MG $  1,178.00
$ 1,240.00

What is the usage and chemical information of (R)-Hydroxy Des(boric Acid) Bortezomib ?


(R)-Hydroxy Des(boric Acid) Bortezomib is a chemical compound that is used in the treatment of certain types of cancer. It is a derivative of bortezomib, which is a proteasome inhibitor that is used to treat multiple myeloma and mantle cell lymphoma. The addition of the (R)-Hydroxy Des(boric Acid) group to bortezomib increases its potency and selectivity, making it an effective treatment option for these types of cancers. Chemically, (R)-Hydroxy Des(boric Acid) Bortezomib is a boronic acid derivative that inhibits the activity of the proteasome enzyme, which is responsible for breaking down proteins in cells. By inhibiting this enzyme, the compound prevents the breakdown of certain proteins that are necessary for the survival of cancer cells. This leads to the accumulation of toxic proteins within the cells, which ultimately results in their death. The usage of (R)-Hydroxy Des(boric Acid) Bortezomib is typically limited to patients who have not responded to other treatments, or who have relapsed after previous treatment. It is administered intravenously, usually in combination with other chemotherapy drugs. Common side effects of the drug include nausea, vomiting, fatigue, and low platelet counts. Overall, (R)-Hydroxy Des(boric Acid) Bortezomib has proven to be an effective treatment option for certain types of cancer, and its chemical properties make it a promising avenue for further research and development.

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