(±)-Nicotine-d7 (N-methyl-d3; pyridine-d4)

(±)-Nicotine-d7 (N-methyl-d3; pyridine-d4) is a labeled form of nicotine, which is a naturally occurring alkaloid found in tobacco plants. It is widely used in research studies as a tracer for the investigation of nicotine metabolism, pharmacokinetics, and pharmacodynamics. The isotopic labeling of Nicotine-d7 enables researchers to differentiate it from the non-labeled nicotine and precisely trace the metabolic pathways of nicotine in the human body. Nicotine-d7 is also used in the development of nicotine addiction therapies and smoking cessation drugs. The labeled nicotine can be used to study the binding affinity of nicotine to various receptors in the brain and the effects of nicotine on neurotransmitter release. Chemically, Nicotine-d7 is a mixture of two enantiomers, (R)-nicotine-d7 and (S)-nicotine-d7. These enantiomers have the same chemical formula but differ in their spatial arrangement of atoms. The deuterium labeling is achieved by replacing some of the hydrogen atoms in nicotine with deuterium atoms, which are stable isotopes of hydrogen. This labeling improves the mass spectrometry detection of nicotine and enables researchers to track its distribution and metabolism in the body. In conclusion, Nicotine-d7 is a valuable tool for research in the fields of nicotine addiction, pharmacology, and toxicology. Its isotopic labeling allows for precise tracking of nicotine metabolism in the human body, making it an essential component in the development of smoking cessation drugs and nicotine addiction therapies.