12-Ketodeoxycholic acid-d2

12-Ketodeoxycholic acid-d2 is a deuterated form of 12-Ketodeoxycholic acid, which is a bile acid that is synthesized in the liver and plays a crucial role in the emulsification and absorption of dietary fats and fat-soluble vitamins. The deuterated form of the acid is produced by replacing certain hydrogen atoms with deuterium atoms, which are heavier and more stable isotopes of hydrogen. This modification enhances the acid's stability and makes it suitable for use in research and analytical applications. The chemical formula of 12-Ketodeoxycholic acid-d2 is C24H39D2O4, and its molecular weight is 405.61 g/mol. It is a white or off-white powder that is soluble in organic solvents such as methanol, ethanol, and chloroform, but insoluble in water. The acid is typically supplied as a dry powder or a solution in a suitable solvent. In research applications, 12-Ketodeoxycholic acid-d2 is used as an internal standard in mass spectrometry-based analysis of bile acids and their metabolites. It is also used in metabolic studies to investigate the role of bile acids in lipid metabolism and their potential as therapeutic targets for metabolic disorders such as obesity and diabetes. Additionally, it can be used in drug discovery and development to assess the pharmacokinetics and metabolism of potential drug candidates.