17α-Ethynylestradiol 13C3

[13C3]-17α-Ethynylestradiol is a synthetic estrogen that is used in research studies to understand the physiological effects of estrogen on the body. It is labeled with three 13C isotopes to aid in the identification and quantification of the compound in biological samples. This compound is chemically similar to the naturally occurring estrogen, estradiol, but it has an ethynyl group at the 17α position, which makes it more potent and longer-lasting than estradiol. As a result, it is commonly used in hormonal contraceptives to prevent ovulation and as a treatment for menopausal symptoms and certain types of cancers. [13C3]-17α-Ethynylestradiol is absorbed through the gastrointestinal tract and metabolized in the liver. It has a half-life of approximately 26 hours and is excreted in the urine and feces. The compound has a high binding affinity to estrogen receptors, which are present in many tissues in the body, including the reproductive system, breast tissue, and bone. This compound is commonly used as a reference standard in analytical chemistry and biochemistry studies to determine the concentration of endogenous estrogens in biological samples. It is also used in toxicology studies to understand the effects of long-term exposure to synthetic estrogens on human health. However, due to its potency and potential side effects, it should only be used in a controlled laboratory setting under the guidance of trained professionals.