2-Deoxyguanosine-15N5

2-Deoxyguanosine-15N5 is a stable isotope labeled compound that is primarily used in scientific research for various applications. It is a modified form of the naturally occurring nucleoside 2-deoxyguanosine, where five nitrogen atoms are replaced with stable isotopes of nitrogen-15. This labeling makes it an ideal compound for metabolic labeling studies, mass spectrometry-based proteomics, and biomolecular NMR spectroscopy. 2-Deoxyguanosine-15N5 is commonly used in the study of DNA replication, repair, and synthesis. It is also used in the study of DNA methylation and epigenetics. This compound is used as a precursor for the synthesis of DNA and RNA molecules that are labeled with stable isotopes of nitrogen-15. This labeling technique allows researchers to track the movement of molecules through metabolic pathways and determine the structure and function of biomolecules in living cells. Chemically, 2-Deoxyguanosine-15N5 is a white crystalline powder that is soluble in water and other polar solvents. It has a molecular weight of 270.22 g/mol and a melting point of 234-236°C. It is stable under normal storage conditions and should be kept in a dry, cool place away from sources of light and heat. This compound is considered to be non-toxic and non-hazardous, but proper handling and disposal should be followed according to established laboratory protocols.