2-Desethoxy-2-hydroxy-1H-1-Ethyl Candesartan Cilexetil-d5

2-Desethoxy-2-hydroxy-1H-1-Ethyl Candesartan Cilexetil-d5 is a deuterium-labeled derivative of Candesartan Cilexetil, which is a widely used angiotensin II receptor antagonist. This medication is primarily used to treat hypertension or high blood pressure, which is a common medical condition that affects millions of people worldwide. The active ingredient in this medication works by blocking the angiotensin II receptor, which is responsible for regulating blood pressure levels in the body. Chemically, 2-Desethoxy-2-hydroxy-1H-1-Ethyl Candesartan Cilexetil-d5 is a prodrug that undergoes hydrolysis in the liver to form the active metabolite, Candesartan. The deuterium-labeled derivative is used in pharmacokinetic studies to determine the drug's metabolism, bioavailability, and pharmacodynamics. It is also used in drug-drug interaction studies to evaluate the potential interactions of Candesartan with other medications. Candesartan is well-absorbed orally and has a half-life of approximately 9 hours. The medication is primarily eliminated through the liver and kidneys, and dose adjustments may be necessary in patients with hepatic or renal impairment. Common side effects of this medication include dizziness, headache, and fatigue, which are generally mild and resolve with continued use. Overall, 2-Desethoxy-2-hydroxy-1H-1-Ethyl Candesartan Cilexetil-d5 is a useful tool for researchers and clinicians in the field of hypertension management.