2-Hydroxy Atorvastatin Lactone D5

2-Hydroxy Atorvastatin Lactone D5 is a synthetic compound that is used in research studies to investigate the metabolism and pharmacokinetics of atorvastatin, a medication used to lower cholesterol levels and prevent heart disease. Atorvastatin is a member of the statin class of drugs, which work by inhibiting the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, a key enzyme in the cholesterol biosynthesis pathway. Atorvastatin lactone is an active metabolite of atorvastatin, formed by the hydrolysis of the lactone ring in the parent compound. 2-Hydroxy Atorvastatin Lactone D5 is labeled with deuterium at five positions, which allows it to be used as a tracer in metabolic studies. It is metabolized in a similar manner to atorvastatin lactone, and its presence in biological samples can be quantified using mass spectrometry. This information can be used to determine the pharmacokinetic properties of atorvastatin and its metabolites, such as their absorption, distribution, metabolism, and excretion. The chemical formula of 2-Hydroxy Atorvastatin Lactone D5 is C33H30D5F2O5, and its molecular weight is 569.64 g/mol. It is a white to off-white powder that is soluble in organic solvents such as methanol and acetonitrile. It should be stored at -20°C in a dry, sealed container, away from light and moisture. As with all research chemicals, proper handling and disposal procedures should be followed to minimize the risk of exposure and harm.