4',4-O,O-Dimethylcurcumin-D6

4',4-O,O-Dimethylcurcumin-D6 (DMCDC6) is a deuterated derivative of curcumin, a natural polyphenol found in turmeric. DMCDC6 is often used in biochemical and medicinal research as a stable isotope-labeled internal standard for quantification of curcuminoids and their metabolites in biological samples. DMCDC6 has a molecular formula of C24D6H22O6 and a molecular weight of 394.48 g/mol. Its chemical structure consists of two methoxy groups and two methyl groups attached to the phenyl rings of curcumin. The deuterium atoms are substituted at the four carbon positions adjacent to the methoxy groups, which enhances the stability and sensitivity of DMCDC6 in mass spectrometry analysis. DMCDC6 has shown anti-inflammatory, antioxidant, and anticancer properties similar to curcumin. However, the deuterated derivative has a longer half-life and bioavailability in vivo due to the increased resistance to metabolic degradation and clearance. This makes DMCDC6 a valuable tool for studying the pharmacokinetics and pharmacodynamics of curcuminoids in various disease models. In conclusion, 4',4-O,O-Dimethylcurcumin-D6 is a useful chemical compound for researchers investigating the biological effects of curcuminoids. Its stable isotope-labeled properties allow for accurate quantification and analysis, while its enhanced stability and bioavailability provide insights into the potential therapeutic applications of curcuminoids.