4'-Hydroxy Nimesulide-d4
| Product Name | 4'-Hydroxy Nimesulide-d4 |
|---|---|
| Alternate Names | Nimesulide Stable Isotopes, Stable Isotopes of Nimesulide |
| CAT No. | CS-O-35408 |
| CAS No. | 109032-22-6(Unlabeled) |
| Category | Stable Isotopes |
| Stock | Enquire |
| Mol. Wt. | 328.33 g/mol |
| Mol. For. | C13H8D4N2O6S |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Nimesulide |
| Smileys | [2H]C1=C([2H])C(OC2=C(NS(=O)(C)=O)C=CC([N+]([O-])=O)=C2)=C([2H])C([2H])=C1O |
| Canonical Smiles | CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=C(C=C2)O |
| InchIKey | XYHFQSKAUPPPBY-UHFFFAOYSA-N |
| Inchl | InChI=1S/C13H12N2O6S/c1-22(19,20)14-12-7-2-9(15(17)18)8-13(12)21-11-5-3-10(16)4-6-11/h2-8,14,16H,1H3 |
| IUPAC | N-[2-(4-hydroxyphenoxy)-4-nitrophenyl]methanesulfonamide |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
4'-Hydroxy Nimesulide-d4 is a deuterated form of the non-steroidal anti-inflammatory drug (NSAID) Nimesulide. This compound is used in the treatment of several inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and acute pain. The deuterium atom substitution in 4'-Hydroxy Nimesulide-d4 is intended to improve the drug's pharmacokinetic properties, such as its bioavailability, absorption, and metabolic stability.
The chemical structure of 4'-Hydroxy Nimesulide-d4 consists of a sulfonamide functional group, a pyridine ring, and a hydroxy group at the 4' position. This compound works by inhibiting the activity of cyclooxygenase-2 (COX-2), an enzyme that plays a crucial role in the production of prostaglandins. By reducing prostaglandin formation, 4'-Hydroxy Nimesulide-d4 can reduce pain, inflammation, and fever.
As with all NSAIDs, 4'-Hydroxy Nimesulide-d4 can cause side effects such as gastrointestinal irritation, renal toxicity, and cardiovascular complications. Patients should be carefully monitored for these adverse reactions and advised to take the drug as directed by a healthcare professional. Overall, 4'-Hydroxy Nimesulide-d4 is a promising drug candidate for the treatment of inflammatory conditions, and further research is needed to fully understand its pharmacological properties and safety profile.
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Related Compounds
Nimesulide metabolite-D4 | Nimesulide D5 | Nimesulide 13C6 |