4'-Tosyl Mycophenolic Acid-d3

4'-Tosyl Mycophenolic Acid-d3 is a deuterated version of the immunosuppressive drug Mycophenolic Acid (MPA). MPA is used to prevent organ rejection after transplantation by inhibiting the activity of inosine monophosphate dehydrogenase (IMPDH), an important enzyme in the synthesis of guanine nucleotides that are essential for DNA and RNA synthesis in immune cells. 4'-Tosyl Mycophenolic Acid-d3 is a labeled derivative of MPA that contains three deuterium atoms and a tosyl group at the 4' position. The deuterium atoms serve as a tracer to help researchers measure the pharmacokinetics and metabolic fate of MPA in vitro and in vivo. The tosyl group is a common protecting group in organic synthesis that can be easily removed by base-catalyzed hydrolysis to regenerate the parent compound. The chemical formula of 4'-Tosyl Mycophenolic Acid-d3 is C21H16D3NO7S, and its molecular weight is 467.53 g/mol. It is a white to off-white powder that is soluble in polar organic solvents like methanol, ethanol, and dimethyl sulfoxide (DMSO). Its purity and identity can be confirmed by techniques like high-performance liquid chromatography (HPLC) and mass spectrometry (MS). Overall, 4'-Tosyl Mycophenolic Acid-d3 is a useful tool for studying the pharmacology, pharmacokinetics, and metabolism of MPA, which can help improve the efficacy and safety of immunosuppressive therapy in transplant patients.