4-Hydroxy Ketorolac-d4

4-Hydroxy Ketorolac-d4 is a deuterated version of the nonsteroidal anti-inflammatory drug (NSAID) Ketorolac. It is a potent analgesic and anti-inflammatory agent that is used to treat moderate to severe pain and inflammation. The deuterium atoms in the molecule make it easier to track the drug's metabolism and pharmacokinetics in vivo. The drug works by inhibiting the production of prostaglandins, which are responsible for pain, fever, and inflammation. It is a non-selective COX inhibitor, meaning that it inhibits both COX-1 and COX-2 enzymes. This makes it effective in treating a wide range of inflammatory conditions. 4-Hydroxy Ketorolac-d4 is administered orally or intravenously and is rapidly absorbed, with a peak plasma concentration achieved within 30 minutes to an hour. The drug is metabolized in the liver and excreted in the urine. The deuterium-labeled version of Ketorolac allows for more accurate pharmacokinetic studies and can help researchers better understand the drug's efficacy and safety. Like all NSAIDs, 4-Hydroxy Ketorolac-d4 has the potential to cause side effects, including gastrointestinal ulcers, bleeding, and kidney damage. It should be used with caution in patients with a history of these conditions. The drug is contraindicated in patients with a history of hypersensitivity to Ketorolac or other NSAIDs, as well as in patients with severe renal impairment or active bleeding. It should not be used for long-term treatment of chronic pain.