4-Hydroxyantipyrine-D3

4-Hydroxyantipyrine-D3 is a deuterated analogue of 4-hydroxyantipyrine, a metabolite of the analgesic and antipyretic drug, phenazone (also known as antipyrine). This compound is commonly used as an internal standard in pharmacokinetic studies and bioanalytical assays to accurately quantify phenazone and its metabolites in biological matrices. The chemical formula of 4-Hydroxyantipyrine-D3 is C11H9D3N2O2, and it has a molecular weight of 208.26 g/mol. This compound is a white crystalline powder that is stable under normal conditions. It is soluble in most organic solvents, such as methanol, ethanol, and acetonitrile. The primary mechanism of action of phenazone is the inhibition of prostaglandin synthesis, which leads to the reduction of pain and fever. It is rapidly absorbed from the gastrointestinal tract and metabolized in the liver to several metabolites, including 4-hydroxyantipyrine. The deuterated analogue, 4-Hydroxyantipyrine-D3, behaves similarly to its non-deuterated counterpart and can be used to accurately quantify the levels of 4-hydroxyantipyrine and other phenazone metabolites in biological samples. In summary, 4-Hydroxyantipyrine-D3 is a useful tool in pharmacokinetic studies and bioanalytical assays to accurately quantify phenazone and its metabolites. Its chemical properties and mechanism of action make it a valuable compound in the field of pharmaceutical research and development.