5-Hydroxy Leflunomide-d4 (Metabolite M2)

5-Hydroxy Leflunomide-d4 (Metabolite M2) is a deuterated analog of 5-Hydroxy Leflunomide (Metabolite M2), which is a metabolite of the immunomodulatory drug Leflunomide. Leflunomide is used in the treatment of rheumatoid arthritis and is known to inhibit the proliferation of T-cells and B-cells, thereby suppressing the immune system. Metabolite M2 is formed in the liver by the oxidation of Leflunomide by the cytochrome P450 enzyme system. It is primarily excreted in the urine and has a half-life of approximately 2 weeks. Metabolite M2 is known to have similar immunomodulatory effects as Leflunomide, but with less toxicity. The deuterated analog, 5-Hydroxy Leflunomide-d4 (Metabolite M2), is used as an internal standard in pharmacokinetic studies of Leflunomide and its metabolites. It is also used in the development of analytical methods for the detection and quantification of Leflunomide and its metabolites in biological samples. The chemical formula of 5-Hydroxy Leflunomide-d4 (Metabolite M2) is C12H4D4ClNO2. Its molecular weight is 252.67 g/mol. The compound is a white crystalline powder that is soluble in organic solvents such as methanol and acetonitrile. In conclusion, 5-Hydroxy Leflunomide-d4 (Metabolite M2) is an important tool in the study of Leflunomide and its metabolites. Its usage as an internal standard and analytical standard in pharmacokinetic studies and analytical methods development, respectively, is crucial for the accurate detection and quantification of Leflunomide and its metabolites in biological samples.