5-Hydroxynepafenac-d5

5-Hydroxynepafenac-d5 is a deuterated form of 5-hydroxynepafenac, a metabolite of the nonsteroidal anti-inflammatory drug nepafenac. It is used in pharmacokinetic studies to determine the metabolic pathways and elimination of nepafenac in vivo. Nepafenac is a prodrug that is metabolized in the body to form amfenac, which is a potent inhibitor of cyclooxygenase (COX), an enzyme that plays a key role in the inflammatory response. By inhibiting COX, nepafenac reduces inflammation and pain associated with conditions such as cataract surgery and osteoarthritis. 5-Hydroxynepafenac-d5 is a labeled form of 5-hydroxynepafenac that is useful in pharmacokinetic studies because it allows researchers to track the metabolic fate of nepafenac in vivo through the use of mass spectrometry. This information can be used to optimize dosing regimens and improve the safety and efficacy of nepafenac as a therapeutic agent. In terms of chemical information, 5-Hydroxynepafenac-d5 has a molecular weight of 284.34 g/mol and a chemical formula of C14H8D5NO4. Its CAS number is 1422922-20-3. It is a deuterated form of 5-hydroxynepafenac, which means that five of the hydrogen atoms in the molecule have been replaced with deuterium atoms. This labeling does not significantly alter the chemical properties or activity of the compound, but allows for more accurate analysis in pharmacokinetic studies.