5’-Deoxy-5-fluorocytidine-13C,15N2

5’-Deoxy-5-fluorocytidine-13C,15N2, also known as 5-DFCR, is a synthetic compound that is used in cancer treatment. It is a modified version of the naturally occurring nucleoside, cytidine, in which the hydrogen atom at the 5’ carbon is replaced with a fluorine atom. This modification enhances the drug’s antitumor activity by increasing its stability and resistance to enzymatic degradation. 5-DFCR is commonly used in combination with other chemotherapy drugs to treat solid tumors such as breast, lung, and colon cancer. It works by being converted in the body into its active form, 5-fluorouracil (5-FU), which inhibits the growth and replication of cancer cells. 5-FU works by interfering with the synthesis of DNA and RNA, which are essential for the growth and division of cells. The use of 5-DFCR in cancer treatment is supported by extensive research and clinical trials, which have shown its effectiveness in improving patient outcomes. It has also been found to have fewer side effects than other chemotherapy drugs, such as nausea, vomiting, and hair loss. In terms of chemical properties, 5-DFCR is a nucleoside analogue that contains isotopes of carbon and nitrogen. Its molecular formula is C9H10C13N3O4F and its molecular weight is 335.19 g/mol. It is soluble in water and has a melting point of 234-236°C. Its chemical structure is similar to that of other nucleoside analogues, such as gemcitabine and cytarabine, which are also used in cancer treatment.