6-O-Desmethyl Donepezil-d5

6-O-Desmethyl Donepezil-d5 is a deuterated form of the drug Donepezil, which is a medication used for the treatment of Alzheimer's disease. It works by increasing the level of acetylcholine in the brain, a neurotransmitter that is involved in memory and learning. 6-O-Desmethyl Donepezil-d5 is a stable isotope-labeled analog of the parent drug, which is used in pharmacokinetic and pharmacodynamic studies to determine the metabolism, elimination, and efficacy of the drug. The chemical formula of 6-O-Desmethyl Donepezil-d5 is C24H28D5N3O3, and its molecular weight is 416.59 g/mol. It is a white to off-white powder that is soluble in water and organic solvents. The deuterium substitution in the molecule enhances the stability of the drug and helps in the identification and quantification of the drug in biological samples. The recommended dosage of Donepezil is 10 mg per day, and it is usually taken at bedtime. The drug is metabolized in the liver and excreted in the urine. The use of 6-O-Desmethyl Donepezil-d5 in research studies can provide valuable information on the pharmacokinetics and pharmacodynamics of the drug and can help in the development of more effective treatments for Alzheimer's disease.