6-O-Methyl Mycophenolic Acid Methyl Ester-d9

6-O-Methyl Mycophenolic Acid Methyl Ester-d9 is a deuterated derivative of 6-O-Methyl Mycophenolic Acid Methyl Ester, an immunosuppressive drug used to prevent organ rejection in transplant patients. The d9 labeling refers to the incorporation of nine deuterium atoms into the molecule, providing a valuable tool for pharmacokinetic studies. The chemical formula of 6-O-Methyl Mycophenolic Acid Methyl Ester-d9 is C22H18D9O7, and its molecular weight is 443.54 g/mol. Its structure includes a mycophenolic acid moiety, which is a potent inhibitor of inosine monophosphate dehydrogenase, the enzyme responsible for the de novo synthesis of guanine nucleotides. This inhibition leads to a reduction in the proliferation of T and B lymphocytes, which are involved in the immune response. 6-O-Methyl Mycophenolic Acid Methyl Ester-d9 is typically used as an internal standard in liquid chromatography-mass spectrometry (LC-MS) analyses of 6-O-Methyl Mycophenolic Acid Methyl Ester concentrations in biological fluids. The incorporation of deuterium atoms into the molecule allows for accurate quantification of the drug in complex matrices, as it eliminates the effects of ion suppression and matrix effects. In summary, 6-O-Methyl Mycophenolic Acid Methyl Ester-d9 is a useful tool for pharmacokinetic studies of mycophenolic acid derivatives, particularly in the field of transplant medicine. Its deuterium labeling provides a reliable internal standard for LC-MS analyses, enabling accurate quantification of these drugs in biological fluids.