alpha-Methyl-L-tyrosine-D3

Alpha-Methyl-L-tyrosine-D3, also known as AMT-D3, is a stable isotope-labeled analogue of alpha-Methyl-L-tyrosine (AMT). AMT-D3 is a non-natural amino acid which is commonly used as a biochemical tool in research and medical applications. AMT-D3 is primarily used as a tracer molecule in the study of protein metabolism, brain neurotransmitter function, and the regulation of catecholamine synthesis. AMT-D3 is an inhibitor of the enzyme tyrosine hydroxylase, which is responsible for the conversion of tyrosine to L-DOPA, the precursor to dopamine and norepinephrine. By inhibiting tyrosine hydroxylase, AMT-D3 effectively decreases the synthesis of catecholamines, leading to changes in neurotransmitter function and metabolism. This makes it a valuable tool for studying the underlying mechanisms of various neurological disorders, such as Parkinson's disease, schizophrenia, and depression. In addition to its uses in research and medical applications, AMT-D3 is also used as a reference standard for the quantification of catecholamines in biological samples. This is due to its stable isotope labeling, which allows for accurate and precise measurement of catecholamine levels through mass spectrometry. Overall, AMT-D3 is an important biochemical tool that has widespread applications in the fields of neuroscience, pharmacology, and medical research. Its ability to modulate catecholamine synthesis and function makes it a valuable tool for studying the underlying mechanisms of various neurological disorders, and its use as a reference standard allows for accurate and precise measurement of catecholamine levels in biological samples.