Alvimopan D5

Product Name Alvimopan D5
Alternate Names Alvimopan Stable Isotopes, Stable Isotopes of Alvimopan
CAT No. CS-O-00769
CAS No. 1217616-62-0
Category Stable Isotopes
Stock Enquire
Mol. Wt. Not Available
Mol. For. Not Available
Hazardous This is not a Hazardous Compound
COA View Sample COA
MSDS View Sample MSDS
Parent API Alvimopan
Industry Forensic
Smileys CC1CN(CCC1(C)C2=CC(=CC=C2)O)CC(CC3=CC=CC=C3)C(=O)NCC(=O)O
Canonical Smiles CC1CN(CCC1(C)C2=CC(=CC=C2)O)CC(CC3=CC=CC=C3)C(=O)NCC(=O)O
InchIKey UPNUIXSCZBYVBB-GAGGCGQMSA-N
Inchl InChI=1S/C25H32N2O4/c1-18-16-27(12-11-25(18,2)21-9-6-10-22(28)14-21)17-20(24(31)26-15-23(29)30)13-19-7-4-3-5-8-19/h3-10,14,18,20,28H,11-13,15-17H2,1-2H3,(H,26,31)(H,29,30)/t18-,20-,25+/m0/s1/i3D,4D,5D,7D,8D
IUPAC 2-[[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl]-3-(2,3,4,5,6-pentadeuteriophenyl)propanoyl]amino]acetic acid
Controlled No
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What is the usage and chemical information of Alvimopan D5 ?


Alvimopan D5 is a deuterated form of Alvimopan, a selective antagonist of the mu-opioid receptor that is used to treat postoperative ileus (POI). POI is a common complication after major abdominal surgery, characterized by delayed gastrointestinal motility that leads to nausea, vomiting, and abdominal distension. Alvimopan D5 works by blocking the effects of opioids on the gastrointestinal tract, thus accelerating the recovery of bowel function after surgery. Chemically, Alvimopan D5 is a white to off-white crystalline powder that is soluble in water. Its molecular formula is C25H24D5N3O4, and its molecular weight is 436.6 g/mol. Alvimopan D5 is a deuterated form of Alvimopan, which means that some of its hydrogen atoms are replaced by deuterium atoms. This modification does not alter the pharmacological activity of the drug but allows for better detection in pharmacokinetic studies. The recommended dose of Alvimopan D5 is 12 mg administered orally 30 minutes to 5 hours before surgery, followed by 12 mg twice daily for up to 7 days after surgery. Alvimopan D5 is contraindicated in patients with known or suspected gastrointestinal obstruction or in those who have received therapeutic doses of opioids for more than 7 consecutive days prior to surgery. Common side effects of Alvimopan D5 include abdominal pain, nausea, vomiting, and diarrhea.

Related Compounds

Alvimopan-D7 | Alvimopan D5 metabolite | Alvimopan metabolite D7 (ADL08-0011), hydrochloride |

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