Aztreonam D6

Aztreonam D6 is a stable isotope labeled version of the antibiotic Aztreonam. It is a synthetic monocyclic beta-lactam antibiotic that is active against gram-negative bacteria. Its mechanism of action involves binding to penicillin-binding proteins (PBPs) and inhibiting cell wall synthesis, leading to bacterial cell death. Aztreonam D6 is primarily used in clinical settings for the treatment of serious infections caused by gram-negative bacteria, including urinary tract infections, pneumonia, sepsis, and skin and soft tissue infections. It is particularly effective against strains of Pseudomonas aeruginosa, a common and drug-resistant bacteria that causes infections in hospitalized patients. Chemically, Aztreonam D6 is a white crystalline powder with a molecular weight of 271.33 g/mol and a molecular formula of C13H11D6N5O5S2. It is stable under normal conditions of use and storage, with a melting point of 194-196°C. In terms of safety, Aztreonam D6 is generally well-tolerated by patients. However, as with all antibiotics, it may cause side effects such as diarrhea, nausea, vomiting, and allergic reactions in some individuals. It is important for healthcare providers to carefully monitor patients receiving Aztreonam D6 to ensure proper dosing and minimize the risk of adverse effects.