Didehydro Atovaquone

Product Name Didehydro Atovaquone
Alternate Names Atovaquone Impurities, Impurities of Atovaquone
CAT No. CS-O-15485
CAS No. 1809464-27-4
Category Impurities
Stock In stock
Mol. Wt. 364.82 g/mol
Mol. For. C₂₂H₁₇ClO₃
Hazardous This is a Hazardous Compound
COA View Sample COA
MSDS View Sample MSDS
Parent API Atovaquone
Purity Not less than 90 %
Smileys O=C(C1=CC=CC=C1C2=O)C(C3CCC(C4=CC=C(Cl)C=C4)=CC3)=C2O
Canonical Smiles C1CC(=CCC1C2=C(C3=CC=CC=C3C(=O)C2=O)O)C4=CC=C(C=C4)Cl
InchIKey HZBPGPKKLODCKG-UHFFFAOYSA-N
Inchl InChI=1S/C22H17ClO3/c23-16-11-9-14(10-12-16)13-5-7-15(8-6-13)19-20(24)17-3-1-2-4-18(17)21(25)22(19)26/h1-5,9-12,15,24H,6-8H2
IUPAC 3-[4-(4-chlorophenyl)cyclohex-3-en-1-yl]-4-hydroxynaphthalene-1,2-dione
Controlled No
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What is the usage and chemical information of Didehydro Atovaquone ?


Didehydro Atovaquone is a drug used to treat malaria caused by Plasmodium falciparum. It is a synthetic compound that inhibits the mitochondrial electron transport chain in the malaria parasite, leading to the death of the parasite. It is usually administered orally in combination with proguanil, another antimalarial drug, to increase its efficacy and reduce the risk of resistance. Chemically, Didehydro Atovaquone is a derivative of Atovaquone, a hydroxynaphthoquinone compound. The addition of a second hydroxy group to Atovaquone creates the didehydro compound. The molecular formula of Didehydro Atovaquone is C22H19ClO5, and it has a molecular weight of 406.84 g/mol. The drug is metabolized in the liver and excreted in the feces. It has a half-life of about 50 hours, which allows for once-daily dosing. It is generally well-tolerated, with the most common side effects being gastrointestinal discomfort and headache. Didehydro Atovaquone is an important weapon in the fight against malaria, a disease that affects millions of people worldwide, particularly in sub-Saharan Africa. Its efficacy, safety, and ease of administration make it a valuable tool in malaria control programs. However, its use should be accompanied by measures to prevent the spread of malaria, such as insecticide-treated bed nets and indoor residual spraying.

Related Compounds

Atovaquone Indene Isomer | cis-Atovaquone | Atovaquone EP Impurity A |

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