Diltiazem N-Oxide

Product Name Diltiazem N-Oxide
Alternate Names Diltiazem Impurities, Impurities of Diltiazem
CAT No. CS-T-90720
CAS No. 142843-04-7
Category Impurities
Stock Enquire
Mol. Wt. 430.52 g/mol
Mol. For. C22H26N2O5S
Hazardous This is a Hazardous Compound
COA View Sample COA
MSDS View Sample MSDS
Parent API Diltiazem
Smileys O=C1[C@H](OC(C)=O)[C@H](C2=CC=C(OC)C=C2)SC3=CC=CC=C3N1CC[N+](C)(C)[O-]
Canonical Smiles CC(=O)OC1C(SC2=CC=CC=C2[N+](C1=O)(CCN(C)C)[O-])C3=CC=C(C=C3)OC
Inchl InChI=1S/C22H26N2O5S/c1-15(25)29-20-21(16-9-11-17(28-4)12-10-16)30-19-8-6-5-7-18(19)24(27,22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+,24?/m1/s1
IUPAC [(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-5-oxido-4-oxo-2,3-dihydro-1,5-benzothiazepin-5-ium-3-yl] acetate
Controlled No
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What is the usage and chemical information of Diltiazem N-Oxide ?

Diltiazem N-Oxide is a potent and selective inhibitor of L-type calcium channels. It is a derivative of diltiazem, which is commonly used to treat hypertension and angina. Diltiazem N-Oxide is used primarily as a research tool to study the role of L-type calcium channels in various physiological and pathological conditions. The chemical structure of Diltiazem N-Oxide includes an N-oxide group, which is responsible for its unique pharmacological properties. This group is known to undergo rapid reduction in vivo, leading to the formation of the parent compound diltiazem. This process is thought to contribute to the pharmacokinetics and pharmacodynamics of Diltiazem N-Oxide. In vitro studies have shown that Diltiazem N-Oxide is a potent inhibitor of L-type calcium channels, with an IC50 value in the low micromolar range. It has also been shown to have selectivity for this channel subtype over other calcium channels. This selectivity makes Diltiazem N-Oxide a valuable tool for investigating the specific roles of L-type calcium channels in various cellular processes. Overall, Diltiazem N-Oxide is a useful research tool for investigating the physiology and pharmacology of L-type calcium channels. Its unique chemical structure and pharmacological properties make it a valuable addition to the research arsenal of scientists studying cardiovascular and neurological diseases.

Related Compounds

O-Desmethyldiltiazem | Diltiazem Sulphone | Diltiazem EP Impurity C Hydrochloride (O-Desmethyl Diltiazem Hydrochloride) | Diltiazem Epoxide (2R,3S) Isomers | Diltiazem-d3 Hydrochloride | Diltiazem monohydrolysed impurity | N-Acetyl Diltiazem | Not in use Diltiazem related compound G | Deacetyl o-demethyl diltiazem | Diltiazem Impurity G (N-Desmethyl Desacetyl Diltiazem Hydrochloride) | N,N-Didesmethyl Diltiazem Hydrochloride | Diltiazem EP Impurity C | N-desmethyl N-nitroso Diltiazem | rel-N-Desmethyl Desacetyl Diltiazem | Diltiazem related compound H | Diltiazem Impurity 2 | Acetoxy Lactam Diltiazem | Diltiazem formamide impurity | Diltiazem EP Impurity A | DTZ-II Diltiazem impurity | N,N-didesmethyl diltiazem | Deacetyl Diltiazem N-Oxide | N,N-Didesmethyl N-tert-Butoxycarbonyl Diltiazem | Diltiazem Impurity 1 | Diltiazem dihydrolysed impurity | dl-cis-Diltiazem | Diltiazem DTZ-I Impurity |

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