Gimeracil 13C3,15N

[13C3,15N]-Gimeracil is a chemical compound used in cancer treatment. It is a derivative of uracil and is used as a component of the chemotherapy drug S-1. S-1 is a combination of three drugs: gimeracil, tegafur, and oteracil potassium. Gimeracil is added to S-1 to increase its effectiveness by inhibiting the breakdown of the other two drugs in the liver. The chemical formula for [13C3,15N]-Gimeracil is C9H10N3O2. The compound contains three carbon-13 isotopes and one nitrogen-15 isotope, making it useful in research involving stable isotope labeling. The use of stable isotopes in research allows for the tracking of molecules through metabolic pathways and the investigation of cellular processes. Due to its activity as an inhibitor of dihydropyrimidine dehydrogenase, [13C3,15N]-Gimeracil has been shown to increase the effectiveness of chemotherapy in patients with certain types of cancer, including gastric and colorectal cancer. It works by preventing the breakdown of tegafur, which is converted to the active drug 5-fluorouracil in the body. This results in higher levels of 5-fluorouracil in the tumor, leading to improved cancer cell death. In summary, [13C3,15N]-Gimeracil is a compound used in cancer treatment to increase the effectiveness of chemotherapy drugs. Its stable isotopes make it useful in research, and its ability to inhibit dihydropyrimidine dehydrogenase results in increased levels of active chemotherapy drugs in the tumor.