Guanine 13C3,15N2

[13C3,15N2]-Guanine is a labeled form of the purine nucleobase guanine, with three carbon-13 atoms and two nitrogen-15 atoms substituted at specific positions. This labeled compound is primarily used in biochemical and pharmacological research to study the metabolism and pathways of guanine and its derivatives in living organisms. The use of labeled guanine allows researchers to track the fate and distribution of the compound in biological systems, as well as to measure the rates of guanine synthesis and degradation. This information can be useful in understanding diseases such as cancer, where abnormal guanine metabolism plays a role in the development of tumors. Chemically, [13C3,15N2]-Guanine is similar to natural guanine, with the only difference being the presence of the labeled isotopes. The compound is stable under normal conditions and can be synthesized through various methods, including chemical synthesis and biosynthesis using labeled precursors. In summary, [13C3,15N2]-Guanine is a valuable tool for biochemical and pharmacological research, providing insight into the metabolism and pathways of guanine in living systems. Its chemical similarity to natural guanine makes it a useful tracer for studying the fate and distribution of guanine in biological systems, with potential applications in cancer research and drug development.