Iso Cyclosporin A
| Product Name | Iso Cyclosporin A |
|---|---|
| Alternate Names | Cyclosporin Impurities, Impurities of Cyclosporin |
| CAT No. | CS-T-56799 |
| CAS No. | 59865-16-6 |
| Category | Impurities |
| Stock | IN-Stock |
| Mol. Wt. | 1202.6 g/mol |
| Mol. For. | C₆₂H₁₁₁N₁₁O₁₂ |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Cyclosporin |
| Purity | 95% |
| Canonical Smiles | CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)OC(C(C(=O)N1)NC)C(C)CC=CC)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C |
| InchIKey | QEKLELUAISGHEL-UHFFFAOYSA-N |
| Inchl | InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52-50(63-18)56(78)66-43(26-2)58(80)68(19)33-48(74)69(20)44(29-34(3)4)55(77)67-49(38(11)12)61(83)70(21)45(30-35(5)6)54(76)64-41(16)53(75)65-42(17)57(79)71(22)46(31-36(7)8)59(81)72(23)47(32-37(9)10)60(82)73(24)51(39(13)14)62(84)85-52/h25,27,34-47,49-52,63H,26,28-33H2,1-24H3,(H,64,76)(H,65,75)(H,66,78)(H,67,77) |
| IUPAC | 30-ethyl-34-hex-4-en-2-yl-4,7,10,12,15,19,25,28-octamethyl-33-(methylamino)-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1-oxa-4,7,10,13,16,19,22,25,28,31-decazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Iso Cyclosporin A is a cyclosporin analog that has shown potent immunosuppressive effects in various preclinical and clinical studies. This compound is structurally similar to cyclosporin A, but it has a cyclic imide ring that is not present in the parent compound. Iso Cyclosporin A has been found to be a potent inhibitor of T-cell activation and proliferation, which makes it a promising drug candidate for the treatment of autoimmune diseases and transplant rejection.
The chemical information of Iso Cyclosporin A shows that it has a molecular weight of 1204.4 g/mol and a molecular formula of C62H111N11O12. It has a melting point of 174-176°C and is sparingly soluble in water. The compound has a high affinity for binding to cyclophilin A, which is a cytosolic protein that plays a key role in the activation of T-cells. This binding results in the inhibition of calcineurin, which is a protein that is required for the activation of nuclear factor of activated T-cells (NFAT). The inhibition of calcineurin ultimately leads to the suppression of T-cell activation and proliferation.
In summary, Iso Cyclosporin A is a promising immunosuppressive drug candidate that has shown potent effects in preclinical and clinical studies. Its chemical properties make it a suitable candidate for further development as a therapeutic agent for autoimmune diseases and transplant rejection.
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Related Compounds
Cyclosporin L | cyclosporine impurity 2 | Cyclosporin E | Cyclosporin Impurity H | Cyclosporin Impurity F | Iso Cyclosporin H Trifluoroacetic Acid Salt (>75% by HPLC) | Cyclosporin V | cyclosporine impurity 1 | Cyclosporine V | Iso Cyclosporine H | Cyclosporin G | Cyclosporin A Dihydro Impurity | Cyclosporin Impurity 2 | Acetoxy Cyclosporine A Acetate |