Lopinavir D8

Product Name Lopinavir D8
Alternate Names Lopinavir Stable Isotopes, Stable Isotopes of Lopinavir
CAT No. CS-O-03071
CAS No. 1224729-35-4
Category Stable Isotopes
Stock IN-Stock
Mol. Wt. 636.85 g/mol
Mol. For. C₃₇H₄₀D₈N₄O₅
Hazardous This is a Hazardous Compound
COA View Sample COA
MSDS View Sample MSDS
Parent API Lopinavir
Therapeutic Antiretroviral / Anti-HIV
Smileys O=C(N[C@H](C[C@H](O)[C@@H](NC(COC(C(C)=CC=C1)=C1C)=O)CC2=CC=CC=C2)CC3=CC=CC=C3)[C@](N(CCCN4)C4=O)([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H]
Controlled No
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Lopinavir D8 is a deuterated analog of the antiretroviral drug lopinavir, which is used to treat human immunodeficiency virus (HIV) infections. Deuterated drugs are those that have been modified by replacing one or more hydrogen atoms with deuterium, a stable isotope of hydrogen. This modification can enhance the drug's pharmacokinetic properties, such as its bioavailability and metabolic stability. Lopinavir D8 is typically administered as a combination therapy with another antiretroviral drug, ritonavir. The two drugs work together to inhibit the HIV protease enzyme, which is necessary for the virus to replicate. This inhibition can reduce the viral load in HIV-infected patients and slow down the progression of the disease. In terms of chemical information, Lopinavir D8 has a molecular formula of C37H47D8N3O5S and a molecular weight of 705.03 g/mol. It is a white to off-white powder that is slightly soluble in water and freely soluble in ethanol. The drug is metabolized in the liver and excreted in the feces and urine. Like other antiretroviral drugs, Lopinavir D8 can cause side effects such as nausea, diarrhea, and headache. Patients taking this drug should also be monitored for potential drug interactions and liver function abnormalities. Overall, Lopinavir D8 is an important treatment option for HIV-infected patients and its deuterated form may offer advantages over the non-deuterated version.

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