Mirabegron trifluoroacetate salt 13C6

[13C6]-Mirabegron trifluoroacetate salt is a stable isotope analog of Mirabegron, which is a selective beta-3 adrenergic receptor agonist used for the treatment of overactive bladder syndrome. The stable isotope labeled compound is used in pharmacokinetic and pharmacodynamic studies to determine the metabolic fate and excretion of the drug, as well as its tissue distribution and target engagement in vivo. The chemical formula of [13C6]-Mirabegron trifluoroacetate salt is C22H24N4O2S2. It is a white to off-white powder with a molecular weight of 456.58 g/mol. The compound is soluble in dimethyl sulfoxide, methanol, and water. The stable isotope labeling of the compound involves the substitution of six carbon atoms with the stable isotope carbon-13. This labeling technique allows for the differentiation of the labeled compound from the endogenous compound during mass spectrometry analysis. During pharmacokinetic studies, [13C6]-Mirabegron trifluoroacetate salt is administered to test subjects and its metabolic products are monitored in biological samples such as urine, plasma, and feces. The labeled compound is also used to determine the drug's target engagement in vivo by analyzing its distribution in various tissues and organs. In conclusion, [13C6]-Mirabegron trifluoroacetate salt is a useful tool in drug metabolism and pharmacokinetic studies, providing valuable information about the fate and distribution of the drug in vivo.