Mono-POC Isopropyl Tenofovir
| Product Name | Mono-POC Isopropyl Tenofovir |
|---|---|
| Alternate Names | Tenofovir Impurities, Impurities of Tenofovir |
| CAT No. | CS-O-10863 |
| CAS No. | 1246812-40-7 |
| Category | Impurities |
| Stock | IN-Stock |
| Mol. Wt. | 445.41 g/mol |
| Mol. For. | C₁₇H₂₈N₅O₇P |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Tenofovir |
| Purity | For long term usage store at -20?C |
| Therapeutic | Antiretroviral / Anti-HIV |
| Smileys | C[C@@H](OC[P](OCOC(OC(C)C)=O)(OC(C)C)=O)CN1C2=NC=NC(N)=C2N=C1 |
| Canonical Smiles | CC(C)OC(=O)OCOP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OC(C)C |
| InchIKey | IHJDJJPKNNEZLC-SGSXECEGSA-N |
| Inchl | InChI=1S/C17H28N5O7P/c1-11(2)28-17(23)25-9-27-30(24,29-12(3)4)10-26-13(5)6-22-8-21-14-15(18)19-7-20-16(14)22/h7-8,11-13H,6,9-10H2,1-5H3,(H2,18,19,20)/t13-,30?/m1/s1 |
| IUPAC | [[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-propan-2-yloxyphosphoryl]oxymethyl propan-2-yl carbonate |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Mono-POC Isopropyl Tenofovir is a potent nucleotide reverse transcriptase inhibitor that is used for the treatment of HIV-1 infection. It is a prodrug of tenofovir, which is converted into its active form, tenofovir diphosphate, in vivo. Mono-POC Isopropyl Tenofovir is designed to have improved pharmacokinetic properties, which allows for once-daily dosing and better patient compliance.
Chemically, Mono-POC Isopropyl Tenofovir is an ester of isopropyl alcohol and tenofovir. The isopropyl group in the molecule enhances its lipophilicity, which allows for better absorption and distribution in the body. The prodrug is rapidly hydrolyzed by esterases in the blood, releasing tenofovir.
Tenofovir diphosphate inhibits the activity of reverse transcriptase, which is essential for the replication of HIV-1. It competes with the natural substrate, deoxyadenosine triphosphate, and incorporates itself into the growing DNA chain, leading to chain termination. Tenofovir diphosphate also inhibits the activity of viral DNA polymerase, which further reduces viral replication.
Mono-POC Isopropyl Tenofovir is administered orally and is rapidly absorbed from the gastrointestinal tract. It has a long half-life of approximately 17 hours, which allows for once-daily dosing. The drug is primarily eliminated via the kidneys, and dosage adjustments are necessary in patients with renal impairment. Overall, Mono-POC Isopropyl Tenofovir is an effective and well-tolerated treatment for HIV-1 infection.
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Related Compounds
Tenofovir alafenamide Impurity 1 | Tenofovir Disoproxil Isopropoxycarbonyl | Mono poc-isopropyl-Tenofovir fumarate salt | Tenofovir EP Impurity C Succinate | Tenofovir Alafenamide Dimer impurity | nPOC-POC Tenofovir | Diethylaminocarboxymethyl POC Tenofovir (Mixture of Diastereomers) | TAF SRS diastereomer | Tenofovir Disoproxil T11 Impurity | Tenofovir alafenamide impurity | Tenofovir Disoproxil Dimer | Tenofovir Impurity 39 (RRR) 2,3-dihydroxysuccinate salt | Tenofovir Alfenamide Amadori Rearrangement product | Tenofovir Impurity 98 | Tenofovir Alafenamide Enantiomer | Tenofovir impurity C fumarate salt | Tenofovir Disoproxil (S)-Isomer fumarate salt | Tenofovir alafenamide Impurity 5 | Tenofovir Isopropyl Carbamate | Ethyl Tenofovir Impurity | Tenofovir disoproxil impurity L fumarate | TAF methyl ester | TAF Propyl ester Impurity | Tenofovir Monomethyl Ester | Tenofovir alafenamide Impurity 2 | Tenofovir Alafenamide (RSR) Diasteroisomer | Tenofovir Bis ((R)-9-(2-Hydroxypropyl)adenine) dimer Acetate salt | Tri-POC Tenofovir Dimer | Tenofovir Impurity 59-D6 | Tenofovir disoproxil impurity L | Tenofovir Alafenamide fumarate | Tenofovir Impurity 62 | Diethylaminocarboxymethyl POC Tenofovir Fumarate | Tenofovir Mono POC Dimer Diethyl amine salt | Tenofovir Impurity 65 | Tenofovir Impurity 59 | Tenofovir Disoproxil T8 Impurity | Tenofovir Disoproxil T5 Impurity | Tenofovir alafenamide lactose Millard Reaction product-2 | Tenofovir alafenamide Methyl ester impurity | Desmethyl Tenofovir disoproxil | Tenofovir alafenamide lactose Millard Reaction product-3 | Tenofovir Disoproxil Fumarate Impurity | Tenofovir DP-IV | nPOC-POC Tenofovir Fumarate | Tenofovir Disoproxil T12 Impurity | Tenofovir isomer 6&1 | TenofovirDisoproxil Ethyl fumarate Impurity | Tenofovir Impurity 36 (RSR) 2,3-dihydroxysuccinate salt | Tenofovir Impurity 35 | Tenofovir Disoproxil T7 Impurity | Tenofovir disoproxil phosphate | tenofovir related impurity | Tenofovir alafenamide monofumarate | Tenofovir diphosphate | Mono ester impurity (Tenofovir) | Tenofovir Related Compound 14 | MOC-POC Tenofovir | Tenofovir Alafenamide Racemic D Isomer | Diisopropyl Tenofovir Fumarate | Tenofovir alafenamide (RRS) diasteroisomer | Tenofovir Related Compound 5 | Tenofovir Impurity 89 | Tenofovir DP-V | Tenofovir alafenamide Impurity 3 | MOC-POC Tenofovir Fumarate | Tenofovir Alafenamide Dimer Impurity II | Mono-POC Methyl Tenofovir Fumarate (Mixture of Diastereomers) | Mono-POC Ethyl Tenofovir | Tenofovir Alafenamide N-hydroxy methyl impurity |