N-Nitroso-N-methyl-4-aminobutyric Acid

Product Name N-Nitroso-N-methyl-4-aminobutyric Acid
CAT No. CS-T-37244
CAS No. 61445-55-4
Category Impurities
Stock In stock
Mol. Wt. 146.14 g/mol
Mol. For. C₅H₁₀N₂O₃
Hazardous This is a Hazardous Compound
COA View Sample COA
MSDS View Sample MSDS
Smileys CN(CCCC(=O)O)N=O
Canonical Smiles CN(CCCC(=O)O)N=O
Inchl InChI=1S/C5H10N2O3/c1-7(6-10)4-2-3-5(8)9/h2-4H2,1H3,(H,8,9)
IUPAC 4-[methyl(nitroso)amino]butanoic acid
Controlled No
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What is the usage and chemical information of N-Nitroso-N-methyl-4-aminobutyric Acid ?

N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) is a synthetic organic compound, commonly used in the production of pharmaceuticals and other chemical products. The compound is a potent carcinogen and has been linked to various types of cancer, including bladder, liver, kidney, and pancreatic cancer. NMBA is formed when the chemical compound N-nitrosodiethylamine (NDEA) reacts with the amino acid L-valine. The compound is typically used in the production of angiotensin II receptor blockers (ARBs), a class of drugs used to treat hypertension and heart failure. However, in recent years, NMBA has been found to be a contaminant in several ARB medications, leading to recalls and regulatory actions by the Food and Drug Administration (FDA). The presence of NMBA in these medications has been linked to various health risks, including an increased risk of cancer. The chemical structure of NMBA consists of a nitroso group (-NO) attached to a methyl group (-CH3) and a 4-aminobutyric acid molecule. The compound is highly reactive and can readily form DNA adducts, which can lead to mutations and the development of cancer. In conclusion, while NMBA has useful applications in the pharmaceutical industry, its potential health risks make it a highly regulated and closely monitored chemical compound. It is important for manufacturers and regulators to ensure that products containing NMBA are free of contaminants and do not pose a threat to public health.

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