Prasugrel hydrochloride salt, inactive metabolite 13C6

[13C6]-Prasugrel hydrochloride salt is a stable isotope-labeled form of Prasugrel hydrochloride, an antiplatelet drug that is used for the prevention of thrombotic events such as heart attack and stroke. The addition of carbon-13 to the molecule enables researchers to track the drug's behavior in the body more accurately, making it a valuable tool for drug metabolism studies. Prasugrel hydrochloride is rapidly absorbed and metabolized in the liver to its inactive metabolite, R-138727. This process is mediated by several cytochrome P450 enzymes, including CYP3A4, CYP2B6, and CYP2C19. The inactive metabolite has a longer half-life than the parent drug, allowing for sustained antiplatelet activity. Studies have shown that [13C6]-Prasugrel hydrochloride salt is safe and well-tolerated in humans. It has been used in clinical trials to investigate the pharmacokinetics and metabolism of Prasugrel hydrochloride in healthy volunteers and patients with coronary artery disease. The chemical formula of [13C6]-Prasugrel hydrochloride salt is C20H20ClNO3S, and its molecular weight is 416.94 g/mol. The stable isotope-labeled carbon-13 atoms are incorporated into the molecule at six different positions, enabling the precise tracking of the drug's fate in the body. In conclusion, [13C6]-Prasugrel hydrochloride salt is a valuable tool for researchers studying the pharmacokinetics and metabolism of Prasugrel hydrochloride. Its use allows for a more accurate understanding of the drug's behavior in the body, which can ultimately lead to the development of safer and more effective antiplatelet therapies.