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Ribociclib impurity-6 is a chemical compound that is commonly used in the pharmaceutical industry as a reference standard and impurity marker for the drug Ribociclib. Ribociclib is a selective inhibitor of cyclin-dependent kinases 4 and 6, which are enzymes that play a key role in the regulation of the cell cycle. Ribociclib impurity-6 is one of several impurities that can be present in Ribociclib, and its presence can impact the purity and quality of the final product.
Chemically, Ribociclib impurity-6 is known as (R)-3-(1-(4-cyanophenyl)ethyl)-1,3-thiazolidin-2-one. It has a molecular weight of 243.29 g/mol and a melting point range of 220-224°C. The compound is typically supplied as a white to off-white powder, and it is soluble in organic solvents such as ethanol, methanol, and DMSO.
In terms of usage, Ribociclib impurity-6 is primarily used as a reference standard for the analysis and characterization of Ribociclib and its related compounds. It is also used as an impurity marker to monitor the quality and purity of Ribociclib during the manufacturing process. The compound is typically analyzed using high-performance liquid chromatography (HPLC) or gas chromatography (GC) techniques, which allow for accurate quantification and identification of impurities. Overall, Ribociclib impurity-6 plays an important role in ensuring the safety and efficacy of Ribociclib-based drugs.
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