Tizoxanide D4

Tizoxanide D4 is a deuterated isotopologue of tizoxanide, which is a potent anti-protozoal drug used to treat gastrointestinal infections caused by protozoa such as Giardia lamblia and Cryptosporidium parvum. Tizoxanide D4 is used as a stable isotope internal standard for quantitative analysis of tizoxanide in biological samples, as it allows for accurate and precise quantification of tizoxanide levels in plasma, urine, and feces. Chemically, Tizoxanide D4 is a derivative of nitazoxanide, which is a prodrug that is rapidly metabolized in vivo to tizoxanide. Tizoxanide D4 is a deuterated analog of tizoxanide, meaning that some of the hydrogen atoms in the molecule have been replaced with deuterium atoms. This modification results in a slight increase in the molecular weight of the compound, which allows for easy differentiation from the endogenous tizoxanide in biological samples. The usage of Tizoxanide D4 is primarily in analytical chemistry and pharmacokinetic studies, where it is used as an internal standard in liquid chromatography-mass spectrometry (LC-MS) based assays for the quantification of tizoxanide in biological matrices. The compound is commercially available in its labeled form, and is used in research laboratories and pharmaceutical companies worldwide. Overall, Tizoxanide D4 is a valuable tool for the accurate and quantitative measurement of tizoxanide levels in biological samples, and is critical in the development and evaluation of new anti-protozoal drugs.