Tranexamic acid 13C6

[13C6]-Tranexamic acid is a stable isotope labeled analogue of tranexamic acid (TXA), which is a synthetic derivative of the amino acid lysine. It is an antifibrinolytic agent that works by inhibiting the activation of plasminogen to plasmin, thereby preventing the breakdown of blood clots. [13C6]-Tranexamic acid is used in research studies to investigate the pharmacokinetics and pharmacodynamics of TXA. Its usage is particularly helpful in mass spectrometry-based studies, as the presence of the stable carbon isotope allows for precise and accurate quantification of the drug in biological samples. The chemical formula of [13C6]-Tranexamic acid is C13H15N1O3, with a molecular weight of 235.27 g/mol. The compound contains six carbon-13 atoms, which are non-radioactive and do not pose any health risks. The half-life of [13C6]-Tranexamic acid in the plasma is similar to that of TXA, with a reported range of 2-3 hours. The drug is primarily eliminated through renal excretion, with approximately 90% of the dose being excreted in the urine within 24 hours of administration. In summary, [13C6]-Tranexamic acid is a useful tool for studying the pharmacology of TXA and for developing new therapeutic strategies for fibrinolytic disorders. Its stable isotope labeling provides a precise and reliable method for assessing drug concentrations in biological samples, which is important for optimizing dosing regimens and improving patient outcomes.