Acamprosate is a drug that is used to treat alcohol dependence. However, during the manufacturing process of Acamprosate, various impurities may be formed. These impurities can affect the quality, purity, and safety of the drug, and may also have a negative impact on its efficacy. Therefore, it is important to identify and control the impurities present in Acamprosate to ensure its quality and safety. Various analytical techniques, such as HPLC, GC-MS, and NMR are used to analyze and characterize Acamprosate impurities.