Alclometasone is a synthetic corticosteroid used to treat various skin conditions. However, during the manufacturing process, trace amounts of impurities may be present. These impurities can affect the quality, safety, and efficacy of the drug. Therefore, it is essential to identify and control these impurities to ensure that the final product is of high quality and meets regulatory requirements. Various analytical techniques are used to detect and quantify these impurities, including high-performance liquid chromatography (HPLC), gas chromatography (GC), and mass spectrometry (MS).