Amphotericin B is a potent antifungal medication that is used to treat severe systemic fungal infections. However, it can contain impurities that may affect its safety and efficacy. These impurities can arise from various sources such as raw materials, manufacturing processes, and storage conditions. The most common impurities include degradation products, residual solvents, and metal impurities. The presence of these impurities can compromise the quality of the drug, leading to adverse effects on patients. Therefore, it is essential to monitor and control the impurities in Amphotericin B to ensure its safety and efficacy.